After adjusting for age, the serum uric acid level in the highest quintile group of total dairy food intake was lower than that in the lowest by 0.21 mg/dl (95% CI 0.04, 0.37; P = 0.02 for trend). After adjusting for other covariates, the difference between the extreme quintiles remained similar (P = 0.005 for trend) (Table 2). Those who consumed milk ?1 time per day had a lower serum uric acid level than did those who did not drink milk (multivariate difference –0.25 [95% CI –0.40, –0.09]; P < 0.001 for trend) (Table 3). Similarly, those who consumed yogurt at least once every other day had a lower uric acid level than did those who did not consume yogurt (multivariate difference ?0.26 [95% CI ?0.41, ?0.12]; P < 0.001 for trend).
These associations were separate of both the almost every other dieting products i analyzed while the other exposure points to have hyperuricemia, eg many years, gender, Bmi, solution creatinine level, blood circulation pressure, liquor fool around with, and you can diuretic fool around with
The outcomes out-of logistic regressions that have hyperuricemia as an excellent dichotomous benefit was in fact comparable. Including, the newest multivariate opportunity proportion (OR) to possess hyperuricemia one particular about highest quintile selection of animal meat consumption as compared with those in the lowest quintile is actually step 1.37 (95% CI step one.05, step 1.80; P = 0.027 for trend) while the relevant And milk intake try 0.74 (95% CI 0.55, 0.99; P = 0.05 for pattern). The fresh new multivariate ORs having hyperuricemia had been 1.58 (95% CI 1.07, 2.34; P = 0.11 getting development) for seafood use ranging from over a half each and every day providing and you may nothing, and you can 0.66 (95% CI 0.forty-eight, 0.89; P = 0.011 to have trend) for dairy application between >step one day-after-day serving and you may not one.
The fresh new serum the crystals height enhanced having growing proteins consumption during the age-adjusted investigation (P = 0.006 getting trend). Yet not, shortly after modifying with other covariates, full protein intake was no more regarding the solution uric acid height (Table dos). When we constant the research playing with times-adjusted necessary protein opinions ( 16 ) as opposed to the portion of time, the outcomes didn’t materially transform (P https://datingranking.net/es/elite-dating-es/ = 0.72 getting trend).
When we repeated our analyses for foods or protein after excluding participants who self-reported gout or were taking allopurinol or uricosuric agents, the results did not materially change. 27 for interaction for all comparisons). The serum uric acid level in the highest quintile group of dairy food intake was lower than that in the lowest quintile by 0.14 mg/dl (95% CI 0.03, 0.25) among those with a BMI <25 kg/m 2 and by 0.30 mg/dl (95% CI 0.13, 0.47) among those with a BMI ?25 kg/m 2 (P = 0.13 for interaction).
Discussion
Within nationwide affiliate attempt men and women, the new solution uric acid peak is receive so you’re able to rather increase that have expanding use of animal meat and you may fish not having complete healthy protein intake. While doing so, i located a critical inverse relationship with milk products application.
The modern studies findings suggest that the intake of chicken and you may fish in wide variety reflective of the nationwide intake increases solution account away from the crystals. In earlier times, the link has been primarily extrapolated off animal otherwise peoples metabolic tests one checked-out the latest effect of small-name fake loading off refined purine (unlike genuine foods) to the gel uric-acid top ( 4-eight ). not, the precise identity and you may level of personal purines in most dinners commonly really-known, especially when cooked otherwise processed ( 8 ), together with bioavailability of numerous purines present in some other items varies dramatically. Particularly, weight loss substitution/introduction experiments revealed that RNA provides a greater impact on this new serum uric acid height than simply do an identical amount of DNA ( seven ), ribomononucleotides higher than nucleic acidic ( 17 ), and you can adenine more than guanine ( 4 ). Therefore, this has been hard to expect whether or not a typically ate dinner otherwise eating classification in fact has an effect on the newest serum uric acid top, incase so, upcoming from the how much cash. The current data truly linked prominent items and you can gel uric acid account and offers the relevant advice.